Danny Rimer from Index Ventures once told me: You have to make the main thing the main thing.
You will always find yourself in situations where there is more work than you can possibly do. Too many emails to follow up to. Too many opportunities to chase.
The problem is: Life is pretty predictably pareto-optimized: 20% yield 80% of the results. Which also means that 80% of your time is spent on… nothing.
Which means: Figure out what the main thing is — and make the main thing the main thing.
Do it. Now.